Author

Keiji Kusumoto

Observed names: K Kusumoto, K. Kusumoto, Keiji KUSUMOTO, 楠本啓司

Observed institutions: Western University, Takeda (Japan)

OpenAlex ID: A5034728533

The Myocardial Na+-H+Exchange: Structure, Regulation, and Its Role in Heart Disease

1999 · Morris Karmazyn, Xiaohong Tracey Gan, et al. · Circulation Research · 411

In Vitro Antagonistic Properties of a New Angiotensin Type 1 Receptor Blocker, Azilsartan, in Receptor Binding and Function Studies

2010 · Mami Ojima, Hideki Igata, et al. · Journal of Pharmacology and Experimental Therapeutics · 156

Na+/H+ exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats

2001 · Keiji Kusumoto, James V. Haist, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 146

Pharmacology of a non‐selective ETA and ETB receptor antagonist, TAK‐044 and the inhibition of myocardial infarct size in rats

1995 · Toshifumi Watanabe, Yumiko Awane, et al. · British Journal of Pharmacology · 91

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Positive Inotropic and Vasoconstrictive Effects of Endothelin-1 in in vivo and in vitro Experiments: Characteristics and the Role of L-Type Calcium Channels

1989 · Toshifumi Watanabe, Keiji Kusumoto, et al. · Journal of Cardiovascular Pharmacology · 67

Effects of a new endothelin antagonist, TAK-044, on post-ischemic acute renal failure in rats

1994 · Keiji Kusumoto, Kazuki Kubo, et al. · Life Sciences · 61

A new endothelin receptor antagonist, TAK-044, shows long-lasting inhibition of both ETA- and ETB-mediated blood pressure responses in rats.

1994 · S Ikeda, Y Awane, et al. · Journal of Pharmacology and Experimental Therapeutics · 60

Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models

2011 · Keiji Kusumoto, Hideki Igata, et al. · European Journal of Pharmacology · 53

Novel, Non-acylguanidine-type Na+/H+ Exchanger Inhibitors: Synthesis and Pharmacology of 5-Tetrahydroquinolinylidene Aminoguanidine Derivatives

2002 · Shoji Fukumoto, Eiko Imamiya, et al. · Journal of Medicinal Chemistry · 51

Cyclic Hexapeptide Endothelin Receptor Antagonists Highly Potent for Both Receptor Subtypes ETA and ETB

1994 · T. Kikuchi, T. Ohtaki, et al. · Biochemical and Biophysical Research Communications · 48

Role of Endogenous Endothelin in Extension of Rabbit Myocardial Infarction

1993 · Keiji Kusumoto, Yumiko Awane, et al. · Journal of Cardiovascular Pharmacology · 40

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists

2014 · Tomoaki Hasui, Norio Ohyabu, et al. · Bioorganic & Medicinal Chemistry · 30

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor

2016 · Yasuhiro Imaeda, Hidekazu Tokuhara, et al. · ACS Medicinal Chemistry Letters · 27

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In vitro and in vivo pharmacology of a structurally novel Na+‐H+ exchange inhibitor, T‐162559

2002 · Keiji Kusumoto, Hideki Igata, et al. · British Journal of Pharmacology · 26

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Role of Endogenous Endothelin in the Extension of Myocardial Infarct Size Studied with the Endothelin Receptor Antagonist, TAK-044

1995 · Masatoyo Kojima, Keiji Kusumoto, et al. · Journal of Cardiovascular Pharmacology · 23

AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model

2016 · Manami Kaneko, Tomoko Satomi, et al. · Biomarkers · 22

Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559

2001 · Tomohiro Kawamoto, Hiroyuki Kimura, et al. · European Journal of Pharmacology · 22

Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile

2018 · Hidekazu Tokuhara, Yasuhiro Imaeda, et al. · Bioorganic & Medicinal Chemistry · 10

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Thieno[2,3-d]pyrimidine-3-acetic Acids A New Class of Nonpeptide Endothelin Receptor Antagonists.

1998 · Nobuo CHO, Yoshi NARA, et al. · Chemical and Pharmaceutical Bulletin · 9

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Antihypertensive and Cardiovascular Effects of a New Potassium Channel Opener, TCV-295, in Rats and Dogs

1994 · Keiji Kusumoto, Yumiko Awane, et al. · Journal of Cardiovascular Pharmacology · 9

Pharmacological Profile in vitro of A New Endothelin Receptor Antagonist, TAK-044.

1994 · Yumiko Awane, Keiji Kusumoto, et al. · The Japanese Journal of Pharmacology · 7

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TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

2018 · Tomoya Hara, Satoshi Nishimura, et al. · PLoS ONE · 6

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Pharmacological characterization of cardiovascular responses induced by endothelin-1 in the perfused rat heart

1996 · Keiji Kusumoto, Akemi Fujiwara, et al. · European Journal of Pharmacology · 4

In vitro and in vivo pharmacological profiles of a novel angiotensin type 1^|^ndash;receptor blocker, azilsartan

2012 · Keiji Kusumoto · Folia Pharmacologica Japonica · 2

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A New Endothelin Receptor Antagonist, TAK-044, Inhibits Both ETA- and ETB-mediated Blood Pressure Responses in Rats.

1994 · Shota Ikeda, Keiji Kusumoto, et al. · The Japanese Journal of Pharmacology · 2

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Works count: 35

Citation count: 1,383

H-index: 17

I10-index: 18