Author

Fred Racine

Observed names: F. Racine, Racine, Fred

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Observed institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

ORCID: 0000-0002-4451-7517

Observed ORCID: 0000-0002-4451-7517

OpenAlex ID: A5035358542

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

2007 · Jun Wang, Srinivas Kodali, et al. · Proceedings of the National Academy of Sciences · 382

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

2014 · Peter Orth, Li Xiao, et al. · Journal of Biological Chemistry · 149

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In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa

2019 · Katherine Young, Ronald E. Painter, et al. · BMC Microbiology · 128

Caspofungin Susceptibility in Aspergillus and Non- Aspergillus Molds: Inhibition of Glucan Synthase and Reduction of β- d -1,3 Glucan Levels in Culture

2006 · Jennifer Nielsen Kahn, Ming-Jo Hsu, et al. · Antimicrobial Agents and Chemotherapy · 63

Exploring the Pharmacokinetic/Pharmacodynamic Relationship of Relebactam (MK-7655) in Combination with Imipenem in a Hollow-Fiber Infection Model

2018 · Jin Wu, Fred Racine, et al. · Antimicrobial Agents and Chemotherapy · 62

Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling

2014 · Lorraine D. Hernandez, Fred Racine, et al. · Antimicrobial Agents and Chemotherapy · 58

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor

2020 · James M. Apgar, Robert R. Wilkening, et al. · Bioorganic & Medicinal Chemistry Letters · 55

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab

2017 · Lorraine D. Hernandez, Heather K. Kroh, et al. · Journal of Molecular Biology · 46

Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection

2014 · Z. Zhang, X. Chen, et al. · Infection and Immunity · 45

A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam

2019 · Pratik Bhagunde, Zufei Zhang, et al. · International Journal of Infectious Diseases · 44

Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin

2015 · Ronald E. Painter, Gregory C. Adam, et al. · Chemistry & Biology · 41

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase

2012 · Brian H. Heasley, Gregory J. Pacofsky, et al. · Bioorganic & Medicinal Chemistry Letters · 35

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

2015 · James M. Apgar, Robert R. Wilkening, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Development of an integrated semi-automated system for in vitro pharmacodynamic modelling

2008 · Liangsu Wang, Michael K. Wismer, et al. · Journal of Antimicrobial Chemotherapy · 9

MK-5204: An orally active β-1,3-glucan synthesis inhibitor

2020 · James M. Apgar, Robert R. Wilkening, et al. · Bioorganic & Medicinal Chemistry Letters · 7

Development of a fully automated platform for agar-based measurement of viable bacterial growth

2022 · Brian Squadroni, William Newhard, et al. · SLAS TECHNOLOGY · 5

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In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa

2020 · Donna Carr, Zufei Zhang, et al. · Open Forum Infectious Diseases · 3

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Assays for Measuring C. difficile Toxin Activity and Inhibition in Mammalian Cells

2017 · Mary Ann Cox, Lorraine D. Hernandez, et al. · InTech eBooks · 1

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Correction for Zhang et al., Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection

2015 · Z. Zhang, X. Chen, et al. · Infection and Immunity

Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab

2013 · P. Orth, L. Xiao, et al. · Worldwide Protein Data Bank

Works count: 28

Citation count: 1,167

H-index: 13

I10-index: 13