Work

Caspofungin Susceptibility in Aspergillus and Non- Aspergillus Molds: Inhibition of Glucan Synthase and Reduction of β- d -1,3 Glucan Levels in Culture

Year: 2006

Type: article

Abstract: Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01610-05

Authors: Jennifer Nielsen Kahn, Ming-Jo Hsu, Fred Racine, Robert Giacobbe, Mary Motyl

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2147605389

FWCI: 5.302

Cites: 6

Cited by: 63

Related to: 10