Author

Yichin Liu

Observed name: Liu, Yichin

Observed institutions: Brigham and Women's Hospital, Roche (United States), Amgen (United States), Harvard University, Genentech, WuXi AppTec (China), Yale University, Evotec (Germany), Gilead Sciences (United States), Pharmaron (China)

ORCID: 0000-0003-0917-1132

Observed ORCID: 0000-0003-0917-1132

OpenAlex ID: A5035637686

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

2012 · Thorlakur Jonsson, Jasvinder K. Atwal, et al. · Nature · 1,741

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 · Yichin Liu, Lara Fallon, et al. · Cell · 786

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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

2016 · Maia Vinogradova, Victor S Gehling, et al. · Nature Chemical Biology · 358

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

2011 · Jasvinder K. Atwal, Yongmei Chen, et al. · Science Translational Medicine · 274

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

2003 · Yichin Liu, Hilal A. Lashuel, et al. · Chemistry & Biology · 257

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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

2014 · Janice A. Maloney, Travis Bainbridge, et al. · Journal of Biological Chemistry · 198

Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates

2017 · Niña G. Caculitan, Josefa dela Cruz Chuh, et al. · Cancer Research · 166

Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

2009 · Zhihua Liu, Robin K. Meray, et al. · Proceedings of the National Academy of Sciences · 141

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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

2018 · Rachana Ohri, Sunil Bhakta, et al. · Bioconjugate Chemistry · 109

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

2017 · BinQing Wei, Janet Gunzner-Toste, et al. · Journal of Medicinal Chemistry · 109

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

2016 · Matthew Volgraf, Benjamin D. Sellers, et al. · Journal of Medicinal Chemistry · 105

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

2011 · David Meininger, Leeanne Zalameda, et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 103

Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships

2012 · Paolo Polucci, Paola Magnaghi, et al. · Journal of Medicinal Chemistry · 95

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

2013 · Peter S. Dragovich, Benjamin P. Fauber, et al. · Bioorganic & Medicinal Chemistry Letters · 93

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

2014 · Snahel Patel, Frederick Cohen, et al. · Journal of Medicinal Chemistry · 90

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

2018 · Dian Su, Katherine R. Kozak, et al. · Bioconjugate Chemistry · 83

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

2012 · Huifen Chen, Bryan K. Chan, et al. · Journal of Medicinal Chemistry · 81

Genomic and Genetic Analysis of Bordetella Bacteriophages Encoding Reverse Transcriptase-Mediated Tropism-Switching Cassettes

2004 · Minghsun Liu, Mari Gingery, et al. · Journal of Bacteriology · 80

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

2017 · Snahel Patel, William J. Meilandt, et al. · Journal of Medicinal Chemistry · 69

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

2013 · Benjamin P. Fauber, Peter S. Dragovich, et al. · Bioorganic & Medicinal Chemistry Letters · 63

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N -(1 H -Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

2015 · Snahel Patel, Seth F. Harris, et al. · Journal of Medicinal Chemistry · 62

Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

2018 · Chengfeng Ren, Aaron O. Bailey, et al. · Analytical Chemistry · 60

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

2017 · Jun Liang, Sharada Labadie, et al. · Bioorganic & Medicinal Chemistry Letters · 57

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

2020 · William S. Sawyer, Neha Srikumar, et al. · Proceedings of the National Academy of Sciences · 55

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

2014 · Angela Oh, Yen‐Ching Ho, et al. · ChemBioChem · 52

Works count: 94

Citation count: 6,072

H-index: 34

I10-index: 51