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Hirotake Tsukamoto

Observed names: H. Tsukamoto, HIROTAKE TSUKAMOTO, Tsukamoto Hirotake, 博丈 塚本, 塚本 博丈, 塚本博丈
Observed institutions: Trudeau Institute, Kyoto University, University of Chicago, Immungenetics (Germany), Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Institute of Medical Science, The University of Tokyo, Tottori University, Kobe University, The University of Tokyo, Kumamoto University
ORCID: 0000-0003-3214-1652
Observed ORCID: 0000-0003-3214-1652
OpenAlex ID: A5046865992
Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment
2018 · Hirotake Tsukamoto, Koji Fujieda, et al. · Cancer Research · 312
Age-associated increase in lifespan of naïve CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
2009 · Hirotake Tsukamoto, Karen Clise-Dwyer, et al. · Proceedings of the National Academy of Sciences · 169
Immune‐suppressive effects of interleukin‐6 on T‐cell‐mediated anti‐tumor immunity
2017 · Hirotake Tsukamoto, Koji Fujieda, et al. · Cancer Science · 168
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Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response
2017 · Takahisa Kouwaki, Masaaki Okamoto, et al. · International Journal of Molecular Sciences · 116
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Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
2022 · Takahiko Akiyama, Tadahito Yasuda, et al. · Cancer Research · 110
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
2015 · Hirotake Tsukamoto, Satoru Senju, et al. · Nature Communications · 103
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Wnt Signaling Regulates Hemopoiesis Through Stromal Cells
2001 · Toshiyuki Yamane, Takahiro Kunisada, et al. · The Journal of Immunology · 92
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Myeloid-Derived Suppressor Cells Attenuate TH1 Development through IL-6 Production to Promote Tumor Progression
2013 · Hirotake Tsukamoto, Ryutaro Nishikata, et al. · Cancer Immunology Research · 88
Aging-associated and CD4 T-cell–dependent ectopic CXCL13 activation predisposes to anti–PD-1 therapy-induced adverse events
2022 · Hirotake Tsukamoto, Yoshihiro Komohara, et al. · Proceedings of the National Academy of Sciences · 85
Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid‐derived suppressor cells
2013 · Hasita Horlad, Yukio Fujiwara, et al. · Molecular Nutrition & Food Research · 69
Identification of Promiscuous KIF20A Long Peptides Bearing Both CD4+ and CD8+ T-cell Epitopes: KIF20A-Specific CD4+ T-cell Immunity in Patients with Malignant Tumor
2013 · Yusuke Tomita, Akira Yuno, et al. · Clinical Cancer Research · 67
Proliferation Potential-Related Protein, an Ideal Esophageal Cancer Antigen for Immunotherapy, Identified Using Complementary DNA Microarray Analysis
2004 · Yoshihiro Yoshitake, Tetsuya Nakatsura, et al. · Clinical Cancer Research · 67
Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections
2017 · Masaaki Okamoto, Hirotake Tsukamoto, et al. · Viral Immunology · 58
Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo
2006 · Seiji Hosaka, Tetsuya Nakatsura, et al. · Cancer Science · 58
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Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly
2020 · Hirotake Tsukamoto, Takahisa Kouwaki, et al. · iScience · 57
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Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects
2010 · Hirotake Tsukamoto, Gail E Huston, et al. · The Journal of Immunology · 57
Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression
2017 · Hirotake Tsukamoto, Koji Fujieda, et al. · Cancer Research · 55
Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
2023 · Yoshihiro Komohara, Daisuke Kurotaki, et al. · Cancer Science · 53
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination
2022 · Yusuke Miyashita, Takanobu Yoshida, et al. · npj Vaccines · 52
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HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling
2020 · Yusuke Higuchi, Jun-ichirou Yasunaga, et al. · Proceedings of the National Academy of Sciences · 52
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Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations
2023 · Yusuke Tomita, Shinya Sakata, et al. · Cancers · 44
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Identification of glypican-3-derived long peptides activating both CD8+and CD4+T cells; prolonged overall survival in cancer patients with Th cell response
2015 · Mohammad A. Sayem, Yusuke Tomita, et al. · OncoImmunology · 36
Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs
2003 · Yasushi Uemura, Satoru Senju, et al. · The Journal of Immunology · 32
Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response
2020 · Hiroaki Mashima, Rong Zhang, et al. · OncoImmunology · 30
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Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells
2006 · A. Irie, K. Harada, et al. · International Immunology · 28
Works count: 151
Citation count: 2,431
H-index: 26
I10-index: 41
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