Get started
Author

Robert W. Carling

Observed names: CARLING R. W. C, Carling, R., Carling, Robert W.; Koning, Patricia Brady, Carling, Robert Weaver, R Carling, R W Carling, R. Carling, R. W. CARLING, R. W. Carling, R.W. Carling, R.W.C. Carling, ROBERT W. CARLING, Robert Carling, Robert W Carling, RobertW. Carling
Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), University of Strathclyde, Sandia National Laboratories California, University of Cambridge, University of Michigan, MSD (UK) Limited (United Kingdom), Sandia National Laboratories
OpenAlex ID: A5080950417
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
2000 · R. M. McKernan, T. W. Rosahl, et al. · Nature Neuroscience · 952
TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates
2005 · John R. Atack, Keith A. Wafford, et al. · Journal of Pharmacology and Experimental Therapeutics · 190
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor
1992 · Paul D. Leeson, Robert W. Carling, et al. · Journal of Medicinal Chemistry · 189
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor
1991 · Paul D. Leeson, Raymond Baker, et al. · Journal of Medicinal Chemistry · 148
3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1
2004 · Robert W. Carling, Kevin W. Moore, et al. · Journal of Medicinal Chemistry · 136
Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists
1997 · Michael Rowley, Janusz J. Kulagowski, et al. · Journal of Medicinal Chemistry · 130
An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties
2004 · Mark S. Chambers, John R. Atack, et al. · Journal of Medicinal Chemistry · 110
Selective, Orally Active γ-Aminobutyric Acid A α5 Receptor Inverse Agonists as Cognition Enhancers
2004 · Francine Sternfeld, Robert W. Carling, et al. · Journal of Medicinal Chemistry · 106
2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the N-methyl-D-aspartate (NMDA) receptor
1992 · Robert W. Carling, Paul D. Leeson, et al. · Journal of Medicinal Chemistry · 99
3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-.alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
1993 · Robert W. Carling, Paul D. Leeson, et al. · Journal of Medicinal Chemistry · 95
The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products
2008 · D.F. Woodward, R.W.C. Carling, et al. · Pharmacology & Therapeutics · 92
Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.
1993 · Robert W. Carling, Paul D. Leeson, et al. · Bioorganic & Medicinal Chemistry Letters · 86
Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes.
1992 · S Grimwood, A M Moseley, et al. · Molecular Pharmacology · 75
Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site
2004 · Leslie J. Street, Francine Sternfeld, et al. · Journal of Medicinal Chemistry · 74
4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine SiteN-Methyl- d -aspartate Antagonists withinVivoActivity
1997 · Robert W. Carling, Paul D. Leeson, et al. · Journal of Medicinal Chemistry · 69
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.
1992 · A C Foster, J A Kemp, et al. · Molecular Pharmacology · 69
Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABAAReceptor Agonists at the α3Subunit
2005 · Michael G. N. Russell, Robert W. Carling, et al. · Journal of Medicinal Chemistry · 63
Direct Conversion of N-Methoxy-N-methylamides (Weinreb Amides) to Ketones via a Nonclassical Wittig Reaction
2005 · John A. Murphy, Aurélien G. J. Commeureuc, et al. · Organic Letters · 57
7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H -1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3- b ]pyridazine: A Functionally Selective γ-Aminobutyric Acid A (GABA A ) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models
2005 · Robert W. Carling, Andrew Madin, et al. · Journal of Medicinal Chemistry · 56
Heat capacities of NaNO3 and KNO3 from 350 to 800 K
1983 · Robert W. Carling · Thermochimica Acta · 55
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D4Receptor with Excellent Selectivity over Ion Channels
1999 · Robert W. Carling, Kevin W. Moore, et al. · Journal of Medicinal Chemistry · 54
Synthesis of medium ring ethers. Part 2. Synthesis of the fully saturated carbon skeleton of Laurencia non-terpenoid ether metabolites containing seven-, eight- and nine-membered rings
1992 · Robert W. Carling, J. Stephen Clark, et al. · Journal of the Chemical Society Perkin Transactions 1 · 52
Discovery of Imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 Subtype Selective Agonists for the Treatment of Anxiety
2006 · Michael G. N. Russell, Robert W. Carling, et al. · Journal of Medicinal Chemistry · 47
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors
1999 · Kevin W. Moore, Katrine Bonner, et al. · Bioorganic & Medicinal Chemistry Letters · 47
A new synthetic method for the preparation of 2,8-disubstituted oxocane derivatives: synthesis of lauthisan and laurenan
1986 · Robert W. Carling, Andrew B. Holmes · Journal of the Chemical Society Chemical Communications · 47
Works count: 101
Citation count: 3,808
H-index: 32
I10-index: 55
Year
Topic
Type