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John Wityak

Discovery of N -(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays
2004 · Louis J. Lombardo, Francis Y. Lee, et al. · Journal of Medicinal Chemistry · 1,299
2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan -Src Kinase Inhibitor
2006 · Jagabandhu Das, Ping Chen, et al. · Journal of Medicinal Chemistry · 399
MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
1998 · John V. Duncia, Joseph B. Santella, et al. · Bioorganic & Medicinal Chemistry Letters · 398
Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation
2004 · Tai-An Lin, Kim W. McIntyre, et al. · Biochemistry · 112
Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors
2003 · Jagabandhu Das, Robert V. Moquin, et al. · Bioorganic & Medicinal Chemistry Letters · 108
A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
2014 · Daniel Todd, Ian Gowers, et al. · PLoS ONE · 92
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Synthesis of 1,3-Diynes Using Palladium-Copper Catalysis
1991 · John Wityak, John B. Chan · Synthetic Communications · 90
Isoxazolines as Potent Antagonists of the Integrin αvβ3
1999 · William J. Pitts, John Wityak, et al. · Journal of Medicinal Chemistry · 89
A Profiling Platform for the Characterization of Transglutaminase 2 (TG2) Inhibitors
2010 · Sabine Schaertl, Michael Prime, et al. · SLAS DISCOVERY · 76
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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors
2006 · Jagabandhu Das, Joseph A. Furch, et al. · Bioorganic & Medicinal Chemistry Letters · 74
5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase
2005 · Chunjian Liu, Stephen T. Wrobleski, et al. · Journal of Medicinal Chemistry · 73
Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists
1997 · John Wityak, Thais M. Sielecki, et al. · Journal of Medicinal Chemistry · 73
Synthesis of Thrombin Inhibitor DuP 714
1995 · John Wityak, Richard A. Earl, et al. · The Journal of Organic Chemistry · 73
Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
2012 · Michael E. Prime, Ole A. Andersen, et al. · Journal of Medicinal Chemistry · 69
Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists
1997 · Chu-Biao Xue, John Wityak, et al. · Journal of Medicinal Chemistry · 67
N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ
2007 · Valentina Molteni, Xiaolin Li, et al. · Journal of Medicinal Chemistry · 66
Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease
2015 · Leticia M. Toledo-Sherman, Michael E. Prime, et al. · Journal of Medicinal Chemistry · 65
Molecular design, synthesis, and structure–Activity relationships leading to the potent and selective p56lck inhibitor BMS-243117
2003 · Jagabandhu Das, James Lin, et al. · Bioorganic & Medicinal Chemistry Letters · 61
Identification of chemokine receptor CCR4 antagonist
2005 · Ashok V. Purandare, Aiming Gao, et al. · Bioorganic & Medicinal Chemistry Letters · 58
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck
2003 · John Wityak, Jagabandhu Das, et al. · Bioorganic & Medicinal Chemistry Letters · 58
Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases
2010 · Chunjian Liu, James Lin, et al. · Journal of Medicinal Chemistry · 57
Imidazoquinoxaline Src-Family Kinase p56Lck Inhibitors: SAR, QSAR, and the Discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity
2004 · Ping Chen, Arthur M. Doweyko, et al. · Journal of Medicinal Chemistry · 57
The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase
2004 · Katerina Leftheris, Gulzar Ahmed, et al. · Journal of Medicinal Chemistry · 50
Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists
2009 · Robert Epple, Christopher Cow, et al. · Journal of Medicinal Chemistry · 49
A 1,3-dipolar cycloaddition route to the 3(R)- and 3(S)-hydroxy-2(S)-arginines
1987 · John Wityak, Steven J. Gould, et al. · The Journal of Organic Chemistry · 49
Works count: 71
Citation count: 4,512
H-index: 33
I10-index: 55
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