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Anita J. Kempf-Grote

Observed names: A.J. Kempf-Grote, Anita J Kempf-Grote, Anita Kempf-Grote
OpenAlex ID: A5086306992
Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors
2007 · Zhonghua Pei, Xiaofeng Li, et al. · Journal of Medicinal Chemistry · 93
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
2006 · Zhonghua Pei, Xiaofeng Li, et al. · Journal of Medicinal Chemistry · 61
Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors
2005 · Clarence J. Maring, Vincent S. Stoll, et al. · Journal of Medicinal Chemistry · 59
Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides
2001 · Gui-Dong Zhu, David L. Arendsen, et al. · Journal of Medicinal Chemistry · 57
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo
2023 · John T. Randolph, Matthew J. O’Connor, et al. · Journal of Medicinal Chemistry · 54
Discovery of ((4 R ,5 S )-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8 H )-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
2006 · Zhonghua Pei, Xiaofeng Li, et al. · Journal of Medicinal Chemistry · 54
Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression
2001 · Andrew O. Stewart, Pramila A. Bhatia, et al. · Journal of Medicinal Chemistry · 52
A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
2007 · Jianguo Ji, William H. Bunnelle, et al. · Biochemical Pharmacology · 41
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
2007 · Bradley J. Backes, Kenton Longenecker, et al. · Bioorganic & Medicinal Chemistry Letters · 39
Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
2006 · David J. Madar, Hana Kopecka, et al. · Journal of Medicinal Chemistry · 37
Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs
2009 · James S Polakowski, Andrew J King, et al. · Journal of Cardiovascular Pharmacology · 15
Use of drug efflux transporter knockout mice to differentiate peripheral from centrally-mediated cardiovascular effects
2011 · Patricia N. Banfor, Scott Mittelstadt, et al. · Journal of Pharmacological and Toxicological Methods · 3
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.
2006 · Zhonghua Pei, Xiaofeng Li, et al. · Journal of Medicinal Chemistry · 2
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Cardiovascular effects of torcetrapib in conscious and pentobarbital anesthetized dogs
2009 · S.W. Mittelstadt, R.A. Nelson, et al. · Journal of Pharmacological and Toxicological Methods
Works count: 14
Citation count: 567
H-index: 11
I10-index: 11
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