Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
Year: 2006
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm060777o
Authors: David J. Madar, Hana Kopecka, Daisy Pireh, Hong Yong, Zhonghua Pei, Xiaofeng Li, Paul E. Wiedeman, Stevan W. Djuric, Thomas W. Von Geldern, Michael G. Fickes, Lakshmi Bhagavatula, Todd McDermott, Steven Wittenberger, Steven J. Richards, Kenton L. Longenecker, Kent D. Stewart, Thomas H. Lubben, Stephen J. Ballaron, Michael A. Stashko, Michelle A. Long, Heidi Wells, Bradley A. Zinker, Amanda K. Mika, David W. A. Beno, Anita J. Kempf-Grote, James Polakowski, Jason Segreti, Glenn A. Reinhart, Ryan M. Fryer, Hing L. Sham, James M. Trevillyan
Institution: Abbott (United States)
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: closed
OpenAlex ID: W1990755598