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Donald E. Awrey

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent
2014 · Jacqueline M. Mason, Dan Chi-Chia Lin, et al. · Cancer Cell · 202
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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
2014 · Peter B. Sampson, Yong Liu, et al. · Journal of Medicinal Chemistry · 181
Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay
2006 · Guillermo A. Senisterra, Eugene Markin, et al. · SLAS DISCOVERY · 129
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The Acute Myeloid Leukemia-Associated Protein, Dek, Forms a Splicing-Dependent Interaction with Exon-Product Complexes
2000 · Tim McGarvey, Emanuel Rosonina, et al. · The Journal of Cell Biology · 128
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Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor
2012 · Nachum Kaplan, Monique Albert, et al. · Antimicrobial Agents and Chemotherapy · 122
The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents
2014 · Peter B. Sampson, Yong Liu, et al. · Journal of Medicinal Chemistry · 117
Transcription Elongation through DNA Arrest Sites
1997 · Donald E. Awrey, Rodney G. Weilbaecher, et al. · Journal of Biological Chemistry · 112
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Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease
2013 · Felix Nitschke, Peixiang Wang, et al. · Cell Metabolism · 92
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Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent
2016 · Yong Liu, Radoslaw Laufer, et al. · ACS Medicinal Chemistry Letters · 90
The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents
2013 · Radoslaw Laufer, Bryan Forrest, et al. · Journal of Medicinal Chemistry · 79
Yeast Transcript Elongation Factor (TFIIS), Structure and Function
1998 · Donald E. Awrey, Nell Shimasaki, et al. · Journal of Biological Chemistry · 72
Yeast Transcript Elongation Factor (TFIIS), Structure and Function
1998 · Valerie K. Olmsted, Donald E. Awrey, et al. · Journal of Biological Chemistry · 58
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Growth of recombinant fibroblasts in alginate microcapsules
1994 · P. L. Chang, G. Hortelano, et al. · Biotechnology and Bioengineering · 58
Purified yeast RNA polymerase II reads through intrinsic blocks to elongation in response to the yeast TFIIS analogue, P37.
1994 · K.R. Christie, D.E. Awrey, et al. · Journal of Biological Chemistry · 58
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents
2015 · Yong Liu, Yunhui Lang, et al. · Journal of Medicinal Chemistry · 57
The Membrane Glycoprotein gp150 Is Encoded by the lagC Gene and Mediates Cell–Cell Adhesion by Heterophilic Binding during Dictyostelium Development
2000 · Jun Wang, Liansheng Hou, et al. · Developmental Biology · 52
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In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS.
1996 · J Wu, D E Awrey, et al. · Proceedings of the National Academy of Sciences · 50
Elongation factor TFIIS contains three structural domains: solution structure of domain II.
1996 · P E Morin, D E Awrey, et al. · Proceedings of the National Academy of Sciences · 48
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides
2014 · Radoslaw Laufer, Grace Ng, et al. · Bioorganic & Medicinal Chemistry · 42
Permeability of alginate microcapsules to secretory recombinant gene products
1996 · D. E. Awrey, M. Tse, et al. · Biotechnology and Bioengineering · 40
Intrinsic Transcript Cleavage in Yeast RNA Polymerase II Elongation Complexes
2003 · Rodney G. Weilbaecher, Donald E. Awrey, et al. · Journal of Biological Chemistry · 37
Systematic Characterization of the Protein Interaction Network and Protein Complexes in Saccharomyces cerevisiae Using Tandem Affinity Purification and Mass Spectrometry
2009 · Mohan Babu, Nevan J. Krogan, et al. · Methods in molecular biology · 36
In vitroactivity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics
2013 · Nachum Kaplan, Donald Awrey, et al. · Journal of Chemotherapy · 35
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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy
2016 · Sze-Wan Li, Yong Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Involvement of a Triton-insoluble Floating Fraction inDictyostelium Cell-Cell Adhesion
2001 · Tony J.C. Harris, Donald E. Awrey, et al. · Journal of Biological Chemistry · 31
Works count: 36
Citation count: 2,055
H-index: 26
I10-index: 29
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