Author

Kazuhiko Tamaki

Observed names: KAZUHIKO TAMAKI, Kazuhiko TAMAKI, Tamaki, Kazuhiko

Institution: Daiichi-Sankyo (Japan)

Observed institutions: Keio University, Yale University, Daiichi-Sankyo (Japan), Ludwig Cancer Research

OpenAlex ID: A5110033371

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 · Gabriele Bergers, Rolf Brekken, et al. · Nature Cell Biology · 2,853

Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile

2008 · Sarah E. Reisman, Joseph M. Ready, et al. · Journal of the American Chemical Society · 172

A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile

2004 · Joseph M. Ready, Sarah E. Reisman, et al. · Angewandte Chemie International Edition · 87

The K252a Derivatives, Inhibitors for the PAK/MLK Kinase Family, Selectively Block the Growth of HAS Transformants

2002 · Thao V Nheu, Hong He, et al. · The Cancer Journal · 69

Increasing the Kinase Specificity of K252a by Protein Surface Recognition

2005 · Tanya L. Schneider, Rebecca S. Mathew, et al. · Organic Letters · 54

Efficient Syntheses of Novel C2‘-Alkylated (±)-K252a Analogues

2001 · Kazuhiko Tamaki, J. Brad Shotwell, et al. · Organic Letters · 26

Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist

2012 · Tsuyoshi Nakamura, Masayoshi Asano, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Syntheses of (−)-(7S)- and (+)-(7R)-K252a dimers

2002 · Kazuhiko Tamaki, Elliott W.D Huntsman, et al. · Tetrahedron Letters · 22

Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. III. Structure elucidation of matlystatins A to F.

1994 · HIDEYUKI HARUYAMA, YOSHIKO OHKUMA, et al. · The Journal of Antibiotics · 22

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A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile

2004 · Joseph M. Ready, Sarah E. Reisman, et al. · Angewandte Chemie · 21

Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. IV. Synthesis and structure-activity relationships of matlystatin b and its stereoisomers.

1994 · KAZUHIKO TAMAKI, SHINWA KURIHARA, et al. · The Journal of Antibiotics · 21

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Preventive Effect of Matrix Metalloproteinase Inhibitor, R‐94138, in Combination with Mitomycin C or Cisplatin on Peritoneal Dissemination of Human Gastric Cancer Cell Line TMK‐1 in Nude Mice

1999 · Naoki Igarashi, Tetsuro Kubota, et al. · Japanese Journal of Cancer Research · 19

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Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists

2015 · Yumi Matsui, Takahiro Yamaguchi, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Synthesis and evaluation of CS-2100, a potent, orally active and S1P3- sparing S1P1 agonist

2012 · Tsuyoshi Nakamura, Masayoshi Asano, et al. · European Journal of Medicinal Chemistry · 17

Total synthesis of matlystatin A

1993 · Kazuhiko Tamaki, Shinwa Kurihara, et al. · Tetrahedron Letters · 17

Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor

2012 · Yuji Nakamura, Teppei Fujimoto, et al. · ACS Medicinal Chemistry Letters · 14

Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors

2012 · Yuji Nakamura, Chie Sugita, et al. · Bioorganic & Medicinal Chemistry Letters · 14

Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor

2013 · Yuji Nakamura, Teppei Fujimoto, et al. · Bioorganic & Medicinal Chemistry · 13

Short step-synthesis and biological activity of Hauptmann's periplanone A and its stereoisomer

1988 · Yoshikazu Shizuri, Kimihiro Matsunaga, et al. · Tetrahedron Letters · 13

A prodrug approach towards the development of tricyclic-based FBPase inhibitors

2010 · Tomoharu Tsukada, Kazuhiko Tamaki, et al. · Bioorganic & Medicinal Chemistry Letters · 11

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

2013 · Yutaka Mori, Yasuyuki Ogawa, et al. · Bioorganic & Medicinal Chemistry · 10

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists

2012 · Masayoshi Asano, Tsuyoshi Nakamura, et al. · Bioorganic & Medicinal Chemistry Letters · 10

Efficient Synthesis of 5-Amino-6-dialkylamino-4-hydroxypentanamide Derivatives for Renin Inhibitors

2011 · Yuji Nakamura, Chie Suzuki, et al. · Heterocycles · 10

Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors

2012 · Yutaka Mori, Yasuyuki Ogawa, et al. · Bioorganic & Medicinal Chemistry Letters · 9

Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors

2015 · Sayaka Suzuki, Takeshi Kuroda, et al. · Bioorganic & Medicinal Chemistry Letters · 8

Works count: 32

Citation count: 3,561

H-index: 15

I10-index: 23