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Haris Jahić
Observed names:
H. Jahic,
Haris Jahic,
Haris Jahic (20983013)
Observed institutions:
AstraZeneca (United Kingdom),
Albert Einstein College of Medicine,
Tango Therapeutics (United States),
Epizyme (United States),
AstraZeneca (United States)
ORCID:
0009-0005-3755-8889
Observed ORCID:
0009-0005-3755-8889
OpenAlex ID:
A5110044367
Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor
2012
·
David E. Ehmann
, Haris Jahić
, et al.
·
Proceedings of the National Academy of Sciences
·
572
PDF
Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases
2013
·
David E. Ehmann
, Haris Jahić
, et al.
·
Journal of Biological Chemistry
·
384
Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48
2014
·
Sushmita D. Lahiri
, Stefano Mangani
, et al.
·
ACS Chemical Biology
·
109
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers
2024
·
Kevin M. Cottrell
, Kimberly J. Briggs
, et al.
·
Journal of Medicinal Chemistry
·
89
Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514
2017
·
Adam B. Shapiro
, Ning Gao
, et al.
·
ACS Infectious Diseases
·
68
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
2018
·
Michael J. Thomenius
, Jennifer Totman
, et al.
·
PLoS ONE
·
62
PDF
SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3
2015
·
Kerry E. Murphy-Benenato
, Brian Dangel
, et al.
·
ACS Medicinal Chemistry Letters
·
30
A Homogeneous, High-Throughput Fluorescence Anisotropy-Based DNA Supercoiling Assay
2010
·
Adam Shapiro
, Haris Jahic
, et al.
·
SLAS DISCOVERY
·
30
PDF
Discovery of Efficacious Pseudomonas aeruginosa -Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model
2015
·
Kerry E. Murphy-Benenato
, Pratik R. Bhagunde
, et al.
·
Journal of Medicinal Chemistry
·
29
A High-Throughput, Homogeneous, Fluorescence Resonance Energy Transfer-Based Assay for Phospho-N-acetylmuramoyl-pentapeptide Translocase (MraY)
2012
·
Adam B. Shapiro
, Haris Jahić
, et al.
·
SLAS DISCOVERY
·
26
MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design
2025
·
Kevin M. Cottrell
, Douglas A. Whittington
, et al.
·
Journal of Medicinal Chemistry
·
16
PDF
Development of an LC–MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis
2004
·
Gejing Deng
, Rong-Fang Gu
, et al.
·
Journal of Pharmaceutical and Biomedical Analysis
·
14
Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations
2013
·
Kerry Murphy-Benenato
, Hongming Wang
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
12
From fragments to leads: novel bacterial NAD + -dependent DNA ligase inhibitors
2014
·
Michael R. Hale
, Claire Brassington
, et al.
·
Tetrahedron Letters
·
9
A Homogeneous, High-Throughput-Compatible, Fluorescence Intensity–Based Assay for UDP-N-Acetylenolpyruvylglucosamine Reductase (MurB) with Nanomolar Product Detection
2011
·
Adam B. Shapiro
, Stephania Livchak
, et al.
·
SLAS DISCOVERY
·
8
The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds
2012
·
Haris Jahić
, Ce Feng Liu
, et al.
·
Biochemical Pharmacology
·
7
LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2025
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
·
Molecular Cancer Therapeutics
·
6
PDF
Supplementary Figure S2 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S6 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S4 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S7 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S1 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S3 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S5 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2026
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
Supplementary Figure S6 from LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
2025
·
Lauren Catherine M. Martires
, Leanne G. Ahronian
, et al.
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Works count:
39
Citation count:
1,471
H-index:
12
I10-index:
13
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