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M. Katharine Holloway

Observed names: M Katharine Holloway, M. K. HOLLOWAY, M. KATHARINE HOLLOWAY, M. Katharine Holloway2, M.K. Holloway, M.Katharine Holloway
ORCID: 0000-0002-0849-2658
Observed ORCID: 0000-0002-0849-2658
OpenAlex ID: A5111587458
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
2004 · Daria J. Hazuda, Neville J. Anthony, et al. · Proceedings of the National Academy of Sciences · 334
Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)
2004 · Shawn J. Stachel, Craig A. Coburn, et al. · Journal of Medicinal Chemistry · 278
A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site
1995 · M. Katharine Holloway, Jenny M. Wai, et al. · Journal of Medicinal Chemistry · 232
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
2012 · Steven Harper, John A. McCauley, et al. · ACS Medicinal Chemistry Letters · 204
4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells
2000 · John S. Wai, Melissa S. Egbertson, et al. · Journal of Medicinal Chemistry · 189
Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
2010 · John A. McCauley, Charles J. McIntyre, et al. · Journal of Medicinal Chemistry · 180
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design
1992 · Wayne J. Thompson, Paula M. D. Fitzgerald, et al. · Journal of Medicinal Chemistry · 170
Thermodynamics of Ligand Binding and Efficiency
2011 · Charles H. Reynolds, M. Katharine Holloway · ACS Medicinal Chemistry Letters · 159
Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease
2008 · Nigel J. Liverton, M. Katharine Holloway, et al. · Journal of the American Chemical Society · 137
Drug-like Density: A Method of Quantifying the “Bindability” of a Protein Target Based on a Very Large Set of Pockets and Drug-like Ligands from the Protein Data Bank
2010 · Robert P. Sheridan, Vladimir N. Maiorov, et al. · Journal of Chemical Information and Modeling · 123
X-Ray Crystal Structure of the HIV Protease Complex with L-700,417, an Inhibitor with Pseudo C2 Symmetry
1991 · Roger Bone, Joseph P. Vacca, et al. · Journal of the American Chemical Society · 123
X-ray crystal structure of the HIV protease complex with L-700,417, an inhibitor with pseudo C2 symmetry
1991 · Roger Bone, Joseph P. Vacca, et al. · Journal of the American Chemical Society · 123
Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases
2004 · Craig A. Coburn, Shawn J. Stachel, et al. · Journal of Medicinal Chemistry · 117
Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders
2023 · David Harrison, Andy Billinton, et al. · Journal of Medicinal Chemistry · 93
Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model
2006 · Shawn J. Stachel, Craig A. Coburn, et al. · Journal of Medicinal Chemistry · 91
Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors
1997 · Timothy E. Johnson, M.Katharine Holloway, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 89
Conformationally biased P3 amide replacements of β-secretase inhibitors
2005 · Shawn J. Stachel, Craig A. Coburn, et al. · Bioorganic & Medicinal Chemistry Letters · 67
An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex
1997 · Amos B. Smith, Ralph Hirschmann, et al. · Journal of Medicinal Chemistry · 64
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation
2006 · Shaun R. Stauffer, Matthew G. Stanton, et al. · Bioorganic & Medicinal Chemistry Letters · 62
Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1
2009 · Shawn J. Stachel, Craig A. Coburn, et al. · Bioorganic & Medicinal Chemistry Letters · 60
Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase
2008 · James C. Barrow, Shaun R. Stauffer, et al. · Journal of Medicinal Chemistry · 60
The Development of Cyclic Sulfolanes as Novel and High-Affinity P2 Ligands for HIV-1 Protease Inhibitors
1994 · Arun K. Ghosh, Hee Yoon Lee, et al. · Journal of Medicinal Chemistry · 59
BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres
2006 · Craig A. Coburn, Shawn J. Stachel, et al. · Bioorganic & Medicinal Chemistry Letters · 58
Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group
2020 · Jian Liu, Younong Yu, et al. · ACS Medicinal Chemistry Letters · 57
Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors
2000 · Bruce D. Dorsey, Colleen McDonough, et al. · Journal of Medicinal Chemistry · 57
Works count: 80
Citation count: 4,125
H-index: 33
I10-index: 58
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