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Sandra J. Hoffman

Observed names: Hoffman, S.J., S J Hoffman, S.J Hoffman, S.J. Hoffman, Sandra Hoffman, Sandra J Hoffman
OpenAlex ID: A5111827790
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
2017 · Philip A. Harris, Scott B. Berger, et al. · Journal of Medicinal Chemistry · 509
DNA-Encoded Library Screening Identifies Benzo[ b ][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
2016 · Philip A. Harris, Bryan W. King, et al. · Journal of Medicinal Chemistry · 291
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Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
1988 · K D Tew, A M Bomber, et al. · PubMed · 211
Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells
2006 · David J. Rickard, Fei-Lan Wang, et al. · Bone · 157
Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate
2001 · George B. Stroup, Michael W. Lark, et al. · Journal of Bone and Mineral Research · 153
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
2013 · Philip A. Harris, Deepak Bandyopadhyay, et al. · ACS Medicinal Chemistry Letters · 143
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock
2018 · Pratyusha Mandal, Yanjun Feng, et al. · Immunity · 133
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Idoxifene: A Novel Selective Estrogen Receptor Modulator Prevents Bone Loss and Lowers Cholesterol Levels in Ovariectomized Rats and Decreases Uterine Weight in Intact Rats
1998 · Mark E. Nuttall, Jeremy N. Bradbeer, et al. · Endocrinology · 90
An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation
2009 · Sanjay Kumar, Christopher J. Matheny, et al. · Bone · 82
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat
2002 · M.W Lark, G.B Stroup, et al. · Bone · 78
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase
2019 · Philip A. Harris, Nicolas Faucher, et al. · Journal of Medicinal Chemistry · 70
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An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury
2020 · Yu Matsuzawa-Ishimoto, Ashley Hine, et al. · Blood · 63
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Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat
2001 · Michael W. Lark, George B. Stroup, et al. · Journal of Bone and Mineral Research · 57
Rapid Inhibition of Thyroxine-Induced Bone Resorption in the Rat by an Orally Active Vitronectin Receptor Antagonist
2002 · Sandra J. Hoffman, Janice Vasko-Moser, et al. · Journal of Pharmacology and Experimental Therapeutics · 42
Glutathione S-transferases in noral and malignant human colon tissue
1991 · Margie L. Clapper, Sandra J. Hoffman, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 40
Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis
1999 · Alison M. Badger, Simon M. Blake, et al. · Journal of Pharmacology and Experimental Therapeutics · 38
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
1999 · William H. Miller, William E. Bondinell, et al. · Bioorganic & Medicinal Chemistry Letters · 36
Glutathione S-transferases in human prostate
1987 · Kenneth D. Tew, Margie L. Clapper, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 34
Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues
2009 · Robert W. Marquis, Amparo M. Lago, et al. · Journal of Medicinal Chemistry · 25
The Effect of Rosiglitazone on Bone Mass and Fragility Is Reversible and Can Be Attenuated With Alendronate
2013 · Sanjay Kumar, Sandra J Hoffman, et al. · Journal of Bone and Mineral Research · 22
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome
2015 · Philip A. Harris, Chaya Duraiswami, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Interleukin 6 production in fetal rat long bone cultures is correlated with PGE2 release and does not correlate with the extent of bone resorption
1994 · Donald R. Bertolini, Bartholomew Votta, et al. · Cytokine · 18
Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy
2001 · G.B Stroup, S.J Hoffman, et al. · Bone · 17
Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue
1991 · Margie L. Clapper, Sandra J. Hoffman, et al. · Carcinogenesis · 11
90 an Acute Model of Cytokine-stimulated Articular Cartilage Degradation in the Dog
2007 · M.A. Pratta, S.J. Hoffman, et al. · Osteoarthritis and Cartilage
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Works count: 28
Citation count: 2,339
H-index: 20
I10-index: 24
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