Elucidation of chronic periodontitis tissue destruction and tissue remodeling mechanism as seen from the periodontal tissue stem cells
Description: Homeostasis of periodontal tissue have been made by local periodontal ligament cells and alveolar bone cells. It has been reported that stem cell-like cells from the trunk migrate to periodontal tissue, and contributes to the regeneration and repair of periodontal tissue. Furthermore, these cells express the specific marker (PDGFRa) of bone marrow mesenchymal stem cells. Mesenchymal stem cells present in the periodontal tissue. The developmental origin of periodontal tissue is neural crest cells. We tried to induce neural crest cells from human iPS cells. It is the goal of this study aims to connect to periodontal tissue regeneration therapy , and obtained the following results. (1) We succeeded establishment of a method to generate human iPS cells derived human neural crest cells. (2) We conformed induced neural crest cells differentiated into osteo, chondro, fat, and peripheral nerve cells. (3) We verified that induced neural crest cells have highest migration potency.
Amount: ¥5,330,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2012-04-01
End date: 2015-03-31
Investigator: Taneaki NAKAGAWA
Institution: Keio University
Funded outputs count: 7
Funder award ID: 24592965
OpenAlex ID: G155191209