Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD
Description: Project Narrative The studies from this proposal will be the first to establish the link between the Wnt/-catenin pathway and monocyte-macrophage differentiation in the resolution of pulmonary fibrosis after injury. This proposal deepen our understanding of Wnt/-catenin interactions in alveolar macrophage-epithelial cell biology and demonstrate that, in both human and mouse, the Wnt/- catenin pathway is critical in regulating lung monocyte-macrophage differentiation. These findings will further our current understanding regarding how host immune responses contribute to the persistent fibrotic reaction and represents a potential new area for prognosis and therapeutic intervention for SSc-ILD.
Funding type: research
Funder scheme: R01
Start date: 2017-12-22
End date: 2024-11-30
Investigator: CARA J GOTTARDI
Institution: NORTHWESTERN UNIVERSITY AT CHICAGO
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 18
Funder award ID: R01HL134800
OpenAlex ID: G2139106136