Alveolar epithelial regeneration in the aging lung
Year: 2023
Type: review
Abstract: Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis. This risk was manifest during the COVID-19 pandemic, when elderly people were disproportionately affected and died from SARS-CoV-2 pneumonia. However, the recent pandemic also provided lessons on lung resilience. An overwhelming majority of patients with SARS-CoV-2 pneumonia, even those with severe disease, recovered with near-complete restoration of lung architecture and function. These observations are inconsistent with historic views of the lung as a terminally differentiated organ incapable of regeneration. Here, we review emerging hypotheses that explain how the lung repairs itself after injury and why these mechanisms of lung repair fail in some individuals, particularly the elderly.
DOI: 10.1172/jci170504
Institution: Northwestern University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
Awards: Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD, G3616187925, G3635687262, Microglia mediate cognitive dysfunction in elderly survivors of pneumonia, G4031877893, Mitochondrial metabolic regulation of lung epithelium: alveolar generation and regeneration, G5514976981, G5871254648, Role for Wnt/beta-catenin signaling in alveolar repair and fibrosis, Disordered Proteostasis as a Driver of Disease in the Aging Lung, G9000026849, G9000316861, Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgery, Alveolar epithelial stress-induced polyploidization in lung injury and repair, Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19, Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center, Pathogenesis of lung injury mediated by lung-restricted antibodies, Mechanisms of Recovery from Viral Pneumonia, Role of mitochondrial metabolism in lung development and repair.
OpenAlex ID: W4387653271