Lipid-Responsive E3 ubiquitin ligases in cholesterol metabolism and atheroscierosis
Description: Relevance to Public Health Cholesterol metabolism and liver X receptor signaling are important determinants of metabolic diseases including atherosclerosis. Elucidating novel lipid signaling pathways that determine plasma and tissue lipid levels is critical to the effort to uncover new opportunities for therapy. Our proposed dissection of two new regulatory circuits mediated by the novel E3 ubiquitin ligases RNF145 and RNF186 will advance our understanding of fundamental physiological and pathophysiological processes and may suggest new interventional strategies.
Funding type: research
Funder scheme: R01
Start date: 2018-01-01
End date: 2021-10-31
Investigator: PETER J TONTONOZ
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 14
Funder award ID: R01HL136618
OpenAlex ID: G4153598705