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Inflammatory response regulation by immune system specific autophagy regulator Rufy4

Description: To elucidate the pathophysiological function of immune system-specific autophagy regulator Rufy4 which is constantly expressed in neutrophil, we investigated the involvement of Rufy4 in NETosis progression. Non-inflammatory neutrophils are isolated from wild type, or rufy4-deficient mice peritoneal wash by density-gradient centrifugation. Although NETosis was induced both in wild type and rufy4 deficient neutrophils, NETs expelled from rufy4 KO neutrophil was drastically reduced as compared to wild type. This result suggested that Rufy4 has a critical role in NETosis progression, but not in initiation.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,550,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2018-04-01

End date: 2021-03-31

Investigator: Seigo TERAWAKI

Institution: Osaka City University

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences