Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling
Year: 2021
Type: article
Abstract: Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine. Moreover, recent studies have revealed that macrophages, especially alternatively activated macrophages (M2) induced by T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, participate in the pathogenesis of allergic diseases. The major source of Th2 cytokines is antigen-specific Th2 cells. To elucidate the relationship between histamine, macrophages, and Th2 cells in allergic inflammation, we established a macrophage-Th2 cell co-culture model in vitro and an antigen-specific Th2 cell transfer mouse model of rhinitis. In vitro analyses indicated that macrophages produce histamine by interacting with antigen-specific Th2 cells through the antigen. Furthermore, Th2 cells and macrophages cooperatively elicited rhinitis in the mouse model. We determined that histamine induces Th2- and macrophage-elicited sneezing responses through H1 receptor signaling, whereas it induces nasal eosinophil infiltrations through H4 receptor signaling. Collectively, these results indicate a novel histamine production mechanism by macrophages, in which Th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling.
Source: PLoS ONE
Institution: Osaka City University
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,749
Awards: Comprehensive study on inflammatory and immune responses through complex linear ubiquitin code, G2079185684, Studies on a novel E3 ligase regulating LUBAC and host defense response, Study on the Novel Cellular Regulatory Mechanism with LUBAC as a Scaffold and Its Application to Disease Therapy, Characterization of linear ubiquitin chain for the elucidation of the molecular pathogenesis of ALS and the development of therapeutic strategies., Novel histamine production mechanism from macrophages, G6091712416, Regulation of biological defense responses via linear ubiquitin chains and its contribution to disease onset, Study on two ubiquitin ligases involved in inflammation and immune signal regulation, Inflammatory response regulation by immune system specific autophagy regulator Rufy4, Construction of DUB MAP for innate immune and inflammatory responses, Advanced Animal Model Support
OpenAlex ID: W3135716486