Linking genome variation to transcriptional network dynamics in human B cells
Description: B cells of the immune system are a leading model for the analysis of gene regulatory networks (GRNs), and variation in the human B cell regulatory genome has been associated with autoimmune diseases and differential vaccine responses. However, there has not been a comprehensive attempt to delineate the cis-regulome of primary human B cells in their resting, activated and terminally differentiated states or to assemble corresponding dynamic GRNs. Based on our recent success in assembling the first comprehensive murine B cell cis-regulome, our inter-disciplinary team is proposing to assemble a human B cell cis-regulome and corresponding dynamic GRNs, and study the consequences of disease-associated non-coding variation in the context of these dynamic GRNs.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2021-08-19
End date: 2026-05-31
Investigator: JISHNU DAS
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Funded outputs count: 21
Funder award ID: U01HG012041
OpenAlex ID: G9000856425