Work

Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3

Year: 2022

Type: article

Source: Nature Immunology

DOI: 10.1038/s41590-022-01210-5

Authors: Stephanie Grebinoski, Qianxia Zhang, Anthony R. Cillo, Sasikanth Manne, Hanxi Xiao, Erin A. Brunazzi, Tracy Tabib, Carly Cardello, Christine G. Lian, George F. Murphy, Robert Lafyatis, E. John Wherry, Jishnu Das, Creg J. Workman, Dario A. A. Vignali

Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Boston Children's Hospital, Harvard University, University of Pennsylvania, Carnegie Mellon University, Brigham and Women's Hospital, Parker Institute for Cancer Immunotherapy

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, LEO Fondet, National Institutes of Health, National Human Genome Research Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Cancer Epidemiology and Genetics, National Cancer Institute

Awards: Testing the role of BATF as a pioneer transcription factor in effector T cells, Special BD LSRFortessaTM, G1644865181, G1796164619, Cellular and transcriptional control of exhausted CD8 T cells lineage dynamics, G2350643484, G2513989095, Investigating a disintegrin and metalloproteinase-mediated Neuropilin 1 cleavage in autoimmune diabetes, G3176075876, Parameters that Underlie Treg Insufficiency in Autoimmune Diabetes, G3892873189, G4553951973, G4834714497, G4848079573, G6558287505, Engineering T cells to Provide Durable Control of HIV-1 Replication, G7381222316, Mechanisms and Immunological Consequences of Host-Virus Interactions, G7742850247, Autoimmunity and Immunopathology Training Program, G8463110223, Linking genome variation to transcriptional network dynamics in human B cells, Durable Alteration of the Human Immune system after Infection or Immunotherapy, Cancer Center Support Grant, Synergies among inhibitory receptors in tolerance and disease, Structure, Function and Mechanistic Analysis of LAG3, Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease, Radiation and checkpoint blockade for cancer immune therapy

OpenAlex ID: W4281565387

FWCI: 8.261

Cites: 84

Cited by: 109

Related to: 10