Keyword

MST2

Description: A serine/threonine protein kinase encoded by the STK3 gene, involved in Hippo signaling and studied in cellular and disease biology.

Primary topic: Hippo pathway signaling and YAP/TAZ (46%)

Wikidata ID: wiki/Q18031760

OpenAlex ID: keywords/mst2

The Hippo Signaling Pathway in Development and Cancer

2010 · Duojia Pan · Developmental Cell · 2,269

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Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

2009 · Dawang Zhou, Claudius Conrad, et al. · Cancer Cell · 913

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Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

2010 · Li Lu, Ying Li, et al. · Proceedings of the National Academy of Sciences · 721

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

2010 · Hai Song, Kinglun Kingston Mak, et al. · Proceedings of the National Academy of Sciences · 583

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

2005 · Eunice H Y Chan, Marjaana Nousiainen, et al. · Oncogene · 581

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

2011 · Dawang Zhou, Yongyou Zhang, et al. · Proceedings of the National Academy of Sciences · 453

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MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

2008 · Maria Praskova, Fan Xia, et al. · Current Biology · 422

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RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

2007 · David Matallanas, David Romano, et al. · Molecular Cell · 416

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

2003 · Jianhang Jia, Wensheng Zhang, et al. · Genes & Development · 391

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Raf Family Kinases: Old Dogs Have Learned New Tricks

2011 · D. Matallanas, M. Birtwistle, et al. · Genes & Cancer · 386

Role of the Kinase MST2 in Suppression of Apoptosis by the Proto-Oncogene Product Raf-1

2004 · Eric O'Neill, Linda Rushworth, et al. · Science · 317

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

2016 · Sachin H. Patel, Fernando D. Camargo, et al. · Gastroenterology · 297

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation

2006 · Bernard A. Callus, Anne M. Verhagen, et al. · FEBS Journal · 276

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

2015 · Jing Geng, Xiufeng Sun, et al. · Nature Immunology · 261

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

2016 · Wantae Kim, Sanjoy Kumar Khan, et al. · Journal of Clinical Investigation · 244

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The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway

2011 · Carole L.C. Poon, Jane I. Lin, et al. · Developmental Cell · 227

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Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells

2018 · Xingrong Du, Jing Wen, et al. · Nature · 223

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

2014 · Alexander W. Lange, Anusha Sridharan, et al. · Journal of Molecular Cell Biology · 207

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The Ste20-like Protein Kinase, Mst1, Dimerizes and Contains an Inhibitory Domain

1996 · Caretha L. Creasy, Diane M. Ambrose, et al. · Journal of Biological Chemistry · 204

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RASSF1A Is Part of a Complex Similar to the Drosophila Hippo/Salvador/Lats Tumor-Suppressor Network

2007 · Cai Guo, Stella Tommasi, et al. · Current Biology · 200

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MST, a Physiological Caspase Substrate, Highly Sensitizes Apoptosis Both Upstream and Downstream of Caspase Activation

2001 · Kyung-Kwon Lee, Takahiro Ohyama, et al. · Journal of Biological Chemistry · 192

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Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

2010 · Balca R. Mardin, Cornelia Lange, et al. · Nature Cell Biology · 184

Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma

2017 · Wantae Kim, Sanjoy Kumar Khan, et al. · Gut · 160

MST kinases in development and disease

2015 · Barry J. Thompson, Erik Sahai · The Journal of Cell Biology · 159

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Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

2015 · Lisheng Ni, Yonggang Zheng, et al. · Genes & Development · 158

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Works count: 409

Citation count: 17,980