Work

Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology

Year: 2014

Type: article

Abstract: We report the complete genome sequences of eight Helicobacter pylori strains isolated from patients with gastrointestinal diseases in Okinawa, Japan. Whole-genome sequencing and DNA methylation detection were performed using the PacBio platform. De novo assembly determined a single, complete contig for each strain. Furthermore, methylation analysis identified virulence factor genotype-dependent motifs.

Source: Genome Announcements

DOI: 10.1128/genomea.00286-14

Authors: Kazuhito Satou, Akino Shiroma, Kuniko Teruya, Makiko Shimoji, Kazuma Nakano, Ayaka Juan, Hinako Tamotsu, Yasunobu Terabayashi, Misako Aoyama, Morimi Teruya, Rumiko Suzuki, Miyuki Matsuda, Akihiro Sekine, Nagisa Kinjo, Fukunori Kinjo, Yoshio Yamaoka, Takashi Hirano

Institutions: Okinawa Industrial Technology Center, Oita University, Kyoto University, University of the Ryukyus, Michael E. DeBakey VA Medical Center, Baylor College of Medicine

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Japan Society for the Promotion of Science, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Molecular Epidemiological Studies of Helicobacter pylori in Southeastern Asia: Search for novel virulence factors and clarification of human migration, Effects of Helicobacter pylori virulence genotypes on disease outcomes, Search for mechanisms how Helicobacter pylori infection causes gastric cancer, Search for the origin of H. pylori, Biological searches for factors interacted with Helicobacter pylori virulence factor OipA, Texas Medical Center Digestive Diseases Center

OpenAlex ID: W2020934585

FWCI: 3.643

Cites: 21

Cited by: 25

Related to: 10