Work

Total Syntheses of (±)-Gusanlung A, (±)-Gusanlung D and 8-Oxyberberrubine and the Uncertainty Concerning the Structures of (-)-Gusanlung A, (-)-Gusanlung D and 8-Oxyberberrubine

Year: 2009

Type: article

Abstract: (+/-)-Gusanlung A, 8-oxyberberrubine and (+/-)-gusanlung D have been synthesized by radical cyclisation of the corresponding 2-aroyl-1-methylenetetra- hydroisoquinolines. The (1)H and (13)C spectra of (-)-gusanlung D were found to be different from those of synthetic (+/-)-gusanlung D. Careful analyses of the (13)C spectra of (-)-gusanlung A and natural 8-oxyberberrubine also cast doubt on the correctness of the structures previously assigned to these two compounds. (+/-)-Gusanlung A and (+/-)-gusanlung D were inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028.

Source: Molecules

DOI: 10.3390/molecules14020726

Authors: Surachai Nimgirawath, Phansuang Udomputtimekakul, Thitima Apornpisarn, Asawin Wanbanjob, Thongchai Taechowisan

Institution: Silpakorn University

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

OpenAlex ID: W2113496554

FWCI:

Cites: 10

Cited by: 2

Related to: 10