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Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor

Year: 2016

Type: article

Abstract: A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to κ- (KOR) and μ-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC50=3.9-11 µM) without binding to MOR.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.c16-00302

Authors: Daisuke Nishiyama, Yuki Sakai, Haruka Sekiguchi, Hiroaki Chiba, Ryosuke Misu, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno

Institution: Kyoto University

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Education, Culture, Sports, Science and Technology, Ministry of Agriculture, Forestry and Fisheries, Japan Society for the Promotion of Science

Awards: Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis, Precise activation based on transition state control using neighboring effect and its medicinal application, Innovative Molecular Transformations Based on Consecutive pai-Activation and Their Medicinal Applications

OpenAlex ID: W2467286018

FWCI: 0.12

Cites: 17

Cited by: 2

Related to: 10