Innovative Molecular Transformations Based on Consecutive pai-Activation and Their Medicinal Applications
Description: As a fundamental study for discovery of lead compounds derived from natural products, development of cascade reactions for construction of drug-like heterocyclic scaffolds and total syntheses of bioactive natural products were carried out. The following remarkable results have been obtained: (1) several novel cascade reactions such as spiroindole synthesis, [4 + 2]-type indole synthesis, fused indolenine synthesis, and pyrrolocarbazole synthesis, have been developed; (2) asymmetric total synthesis of quinocarcin, asymmetric synthesis of a possible precursor of laurendecumallene B, asymmetric formal synthesis of strictamine have been achieved; and (3) potent CK2 inhibitors and isoform selective SphKs inhibitors have been identified.
Amount: ¥25,480,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (A)
Start date: 2012-04-01
End date: 2017-03-31
Investigator: Ohno Hiroaki (lead)
Institution: Kyoto University
Funded outputs count: 30
Funder award ID: 24689001
OpenAlex ID: G7573927872