Work

Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

Year: 2017

Type: article

Abstract: Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c7ob01122a

Authors: Hugo K. H. Fong, Jean Michel Brunel, Arlette Longeon, Marie-Lise Bourguet-Kondracki, David Barker, Brent R. Copp

Institutions: University of Auckland, Centre National de la Recherche Scientifique, Aix-Marseille Université, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Muséum national d'Histoire naturelle, Molécules de Communication et Adaptation des Micro-organismes

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: University of Auckland

OpenAlex ID: W2727329440

FWCI: 0.424

Cites: 35

Cited by: 8

Related to: 10