Year: 2017
Type: article
Abstract: X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the firstin-vivoXDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
Source: Scientific Reports
Authors: Lukas B. Gromann, Fabio De Marco, Konstantin Willer, Peter B. Noël, Kai Scherer, Bernhard Renger, Bernhard Gleich, Klaus Achterhold, Alexander A. Fingerle, Daniela Muenzel, Sigrid Auweter, Katharina Hellbach, Maximilian Reiser, Andrea Baehr, Michaela Dmochewitz, Tobias J. Schroeter, Frieder J. Koch, Pascal Meyer, Danays Kunka, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Roland Proksa, Thomas Koehler, Nataly Wieberneit, Karsten Rindt, Ernst J. Rummeny, Franz Pfeiffer, Julia Herzen
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Deutsche Forschungsgemeinschaft, Gottfried Wilhelm Leibniz Universität Hannover, Munich-Centre for Advanced Photonics, Deutsches Zentrum für Lungenforschung, Horizon 2020 Framework Programme, Leibniz-Gemeinschaft, Institute for Advanced Study, Technische Universität München, H2020 European Research Council
OpenAlex ID: W2734190073