Cryo-XPS for Surface Characterization of Nanomedicines
Year: 2023
Type: article
Abstract: Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of cryo-XPS for the measurement of two PEG-functionalized nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between cryo-XPS and standard XPS measurements indicate the potential of cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.
Language: English
Subfield: Surfaces, Coatings and Films
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: ACT4Nano - Desenvolvimento de metodologias analíticas para acelerar a translação de nanopartículas para a prática clínica, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G6306052364, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, EXpanding Platforms for Efficacious mRNA Therapeutics
OpenAlex ID: W4386917482