Correction: Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation
Year: 2023
Type: erratum
Abstract: Smad Signaling Antagonizes STAT5-mediated Gene Transcription and Mammary Epithelial Cell DifferentiationJournal of Biological ChemistryVol. 283Issue 3PreviewBoth the transforming growth factor-β (TGFβ)/Smad and the prolactin/JAK/STAT pathway are critical to the proper development, maintenance, and function of the mammary epithelial tissue. Interestingly, opposing physiological effects between these two signaling pathways are prominent in the regulation of mammary gland development. However, the exact nature of the biological network existing between the Smad and STAT signal transduction pathways has remained elusive. We identified a novel regulatory cross-talk mechanism by which TGFβ-induced Smad signaling acts to antagonize prolactin-mediated JAK/STAT signaling and expression of target genes. Full-Text PDF Open Access In figure 1D, JAK2 panel was inadvertently reused as βTubulin panel. βTubulin panel in figure 7H was inadvertently used in figure 9B tubulin panel. Amended figures 1D and 9B show the correct blots for βTubulin. The authors state that these corrections do not affect the results or conclusions of the work.Figure 9View Large Image Figure ViewerDownload Hi-res image Download (PPT)
Source: Journal of Biological Chemistry
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4387423151