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Michelle Kasem

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
2012 · P. Douglas Boatman, Brett Lauring, et al. · Journal of Medicinal Chemistry · 54
Complementary Asymmetric Routes to (R)-2-(7-Hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
2012 · Thomas O. Schrader, Benjamin R. Johnson, et al. · Organic Letters · 38
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)
2010 · P. Douglas Boatman, Thomas O. Schrader, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor
2014 · Daniel J. Buzard, Thomas O. Schrader, et al. · Bioorganic & Medicinal Chemistry Letters · 19
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists
2014 · Daniel J. Buzard, Luis Lopez, et al. · ACS Medicinal Chemistry Letters · 17
Diazepine Agonists of the 5-HT2C Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352)
2025 · Albert Ren, Xiuwen Zhu, et al. · Journal of Medicinal Chemistry · 12
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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor
2016 · Thomas O. Schrader, Michelle Kasem, et al. · Bioorganic & Medicinal Chemistry Letters · 8
Asymmetric syntheses of (R)-4-halo-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines, important 5-HT2C agonist precursors
2018 · Thomas O. Schrader, Xiuwen Zhu, et al. · Tetrahedron Letters · 7
Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays
2019 · Albert Ren, Xiuwen Zhu, et al. · Bioorganic & Medicinal Chemistry Letters · 6
Complementary asymmetric routes to fused tricyclic (R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinolines and (R)-1,2,3,4,5,5a,6,7-octahydro-[1,4]diazepino[1,2-a]quinolines
2016 · Thomas O. Schrader, Michelle Kasem, et al. · Tetrahedron Letters · 5
Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor
2021 · Thomas O. Schrader, Xiuwen Zhu, et al. · Bioorganic & Medicinal Chemistry Letters · 1
Works count: 11
Citation count: 201
H-index: 7
I10-index: 6
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