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Ipilimumab as an adjuvant for HIV vaccines

Description: PROJECT NARRATIVE An effective vaccine against HIV is a global health priority. The proposed research will combine two promising approaches to induce effective immune responses against the AIDS virus: immune checkpoint inhibition and persistent immune stimulation. If successful, the data generated from this grant have the potential to ameliorate human suffering and prevent new HIV infections around the world.
Funding type: career_development
Funder scheme: K01
Start date: 2016-08-05
End date: 2020-04-30
Investigator: MAURICIO DE AGUIAR MARTINS
Institution: SCRIPPS FLORIDA
Funded outputs count: 16
Funder award ID: K01OD023032
OpenAlex ID: G2689331663
Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition
2021 · Isabelle M. Castro, Michael J. Ricciardi, et al. · Journal of Virology · 3
Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates
2021 · Lars Hangartner, David Beauparlant, et al. · Science Translational Medicine · 36
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Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome
2020 · Mauricio A. Martins, Lucas Gonzalez-Nieto, et al. · Journal of Virology · 10
A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses
2019 · Alexander S. Hahn, Georg F. Bischof, et al. · Journal of Virology · 8
Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques
2019 · Lucas Gonzalez-Nieto, Isabelle M. Castro, et al. · PLoS Pathogens · 9
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Vaccine protection against SIVmac239 acquisition
2019 · Mauricio A. Martins, Georg F. Bischof, et al. · Proceedings of the National Academy of Sciences · 14
The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08 + Rhesus Macaques
2018 · Mauricio A. Martins, Lucas Gonzalez-Nieto, et al. · Journal of Virology · 7
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
2018 · Young C. Shin, Georg F. Bischof, et al. · PLoS Pathogens · 10
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Mamu-B*17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication
2018 · Mauricio A. Martins, Damien C. Tully, et al. · Journal of Virology · 15
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Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques
2017 · Diogo M. Magnani, Thomas F. Rogers, et al. · Science Translational Medicine · 92
Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine
2017 · Diogo M. Magnani, Cassia G. T. Silveira, et al. · Journal of Virology · 25
Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys
2017 · Diogo M. Magnani, Michael J. Ricciardi, et al. · Molecular Therapy · 14
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Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques
2017 · Mauricio A. Martins, Young C. Shin, et al. · PLoS Pathogens · 17
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Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque
2017 · Mauricio A. Martins, Damien C. Tully, et al. · AIDS Research and Human Retroviruses · 15
What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?
2017 · Mauricio A. Martins, David I. Watkins · Cold Spring Harbor Perspectives in Biology · 21
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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
2016 · Lucas Gonzalez-Nieto, Aline Domingues, et al. · Journal of Visualized Experiments · 14
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