Mamu-B*17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication
Year: 2018
Type: article
Abstract: A better understanding of the immune correlates of protection against HIV might facilitate the development of a prophylactic vaccine. Therefore, we investigated simian immunodeficiency virus (SIV) infection outcomes in rhesus macaques expressing the major histocompatibility complex class I allele Mamu-B*17 . Approximately 21% of Mamu-B*17 + macaques spontaneously controlled chronic phase viremia after SIV infection, an effect that may involve CD8 + T cells targeting Mamu-B*17-restricted SIV epitopes. We vaccinated Mamu-B*17 + macaques with genes encoding immunodominant epitopes in Vif and Nef alone (group 1) or together with env (group 2). Although neither vaccine regimen prevented SIV infection, 5/8 group 2 vaccinees controlled viremia to below detection limits shortly after infection. This outcome, which was not observed in group 1, was associated with vaccine-induced, nonneutralizing Env-binding antibodies. Together, these findings suggest a limited contribution of Vif- and Nef-specific CD8 + T cells for virologic control in Mamu-B*17 + macaques and implicate anti-Env antibodies in containment of SIV infection.
Source: Journal of Virology
DOI: 10.1128/jvi.00690-18
Authors: Mauricio A. Martins, Damien C. Tully, Núria Pedreño-Lopez, Benjamin von Bredow, Matthias G. Pauthner, Young C. Shin, Maoli Yuan, Noemia S. Lima, David J. Bean, Lucas Gonzalez-Nieto, Aline Domingues, Martin J. Gutman, Helen S. Maxwell, Diogo M. Magnani, Michael J. Ricciardi, Varian K. Bailey, John D. Altman, Dennis R. Burton, Keisuke Ejima, David B. Allison, David T. Evans, Eva G. Rakasz, Christopher L. Parks, Myrna C. Bonaldo, Saverio Capuano, Jeffrey D. Lifson, Ronald C. Desrosiers, Todd M. Allen, David I. Watkins
Institutions: University of Miami, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, University of Wisconsin–Madison, Scripps Research Institute, International AIDS Vaccine Initiative, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Emory University, Indiana University Bloomington, Indiana University, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States)
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: A Novel, Logical Approach to HIV Vaccine Development, Can vaccine-induced CD8 T cells prevent chronic phase AIDS virus replication?, Ipilimumab as an adjuvant for HIV vaccines, Fcgamma receptor-mediated suppression of immunodeficiency virus replication, Lentiviral Resistance to Tetherin, G386607036, Optimizing Human B and T Cell Vaccines Against HIV Using Humanized BLT Mice, The Functional Significance of CTL Escape, G5888954722, Gamma-2 Herpesviruses as Vaccine Vectors for AIDS, KIR and MHC Class I Immunogenetics in SIV Infection, Wisconsin National Primate Research Center Support
OpenAlex ID: W2805687301