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The Functional Significance of CTL Escape

Funding type: research
Funder scheme: R37
Start date: 2003-04-01
End date: 2018-11-30
Investigator: DAVID I WATKINS
Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
Funded outputs count: 26
Funder award ID: R37AI052056
OpenAlex ID: G5114635192
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
2022 · Fangzhu Zhao, Zachary T. Berndsen, et al. · Nature Communications · 8
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Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition
2021 · Isabelle M. Castro, Michael J. Ricciardi, et al. · Journal of Virology · 3
Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome
2020 · Mauricio A. Martins, Lucas Gonzalez-Nieto, et al. · Journal of Virology · 10
Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies
2020 · Nuria Pedreño-Lopez, Christine M. Dang, et al. · Molecular Therapy — Methods & Clinical Development · 4
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A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses
2019 · Alexander S. Hahn, Georg F. Bischof, et al. · Journal of Virology · 8
Vaccine protection against SIVmac239 acquisition
2019 · Mauricio A. Martins, Georg F. Bischof, et al. · Proceedings of the National Academy of Sciences · 14
The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08 + Rhesus Macaques
2018 · Mauricio A. Martins, Lucas Gonzalez-Nieto, et al. · Journal of Virology · 7
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
2018 · Young C. Shin, Georg F. Bischof, et al. · PLoS Pathogens · 10
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Mamu-B*17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication
2018 · Mauricio A. Martins, Damien C. Tully, et al. · Journal of Virology · 15
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Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque
2017 · Mauricio A. Martins, Damien C. Tully, et al. · AIDS Research and Human Retroviruses · 15
Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 + T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection
2015 · Mauricio A. Martins, Damien C. Tully, et al. · Journal of Virology · 31
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Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8 + T Cell Killing
2015 · Jennifer N. Rainho, Mauricio A. Martins, et al. · Journal of Virology · 27
Vaccine-induced CD8+ T cells control AIDS virus replication
2012 · Philip A. Mudd, Mauricio A. Martins, et al. · Nature · 175
Escape from CD8+ T Cell Responses in Mamu-B*00801+ Macaques Differentiates Progressors from Elite Controllers
2012 · Philip A Mudd, Adam J Ericsen, et al. · The Journal of Immunology · 37
CD8+T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness DefectsIn Vivo, and Many Revert after Transmission
2011 · Philip A. Mudd, Adam J. Ericsen, et al. · Journal of Virology · 14
Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape
2011 · Nicholas James Maness, Andrew D. Walsh, et al. · Immunogenetics · 5
Reduction of CD4+T CellsIn VivoDoes Not Affect Virus Load in Macaque Elite Controllers
2011 · Philip A. Mudd, Adam J. Ericsen, et al. · Journal of Virology · 14
Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses
2011 · Philip A Mudd, David I Watkins · Current Opinion in HIV and AIDS · 24
CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses
2010 · Patrícia C.C. Neves, Richard A. Rudersdorf, et al. · Vaccine · 36
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CD8 + T Cell Recognition of Cryptic Epitopes Is a Ubiquitous Feature of AIDS Virus Infection
2010 · Nicholas J. Maness, Andrew D. Walsh, et al. · Journal of Virology · 22
The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques—implications for recombinant vaccine design
2010 · Philip A. Mudd, Shari M. Piaskowski, et al. · Immunogenetics · 21
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T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge
2010 · Mauricio A. Martins, Nancy A. Wilson, et al. · Journal of Virology · 46
Robust, Vaccine-Induced CD8+ T Lymphocyte Response against an Out-of-Frame Epitope
2009 · Nicholas J Maness, Nancy A Wilson, et al. · The Journal of Immunology · 21
Is an HIV vaccine possible?
2009 · Nancy A. Wilson, David I. Watkins · The Brazilian Journal of Infectious Diseases · 14
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Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge
2009 · Nancy A. Wilson, Brandon F. Keele, et al. · Journal of Virology · 124
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